Description

3-Keto Sphinganine (D12:0) (Hydrochloride) is a high-purity, synthetic sphingolipid intermediate, specifically the hydrochloride salt of the 3-keto derivative of dodecanoyl sphinganine. This compound serves as a critical building block and analytical standard in advanced lipidomics and metabolic pathway research. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for studying sphingolipid metabolism, enzyme inhibition, and as a precursor for synthesizing more complex bioactive lipids.

Application

• Biochemical Research: As a key intermediate and reference standard for investigating the de novo sphingolipid biosynthesis pathway, particularly the action of serine palmitoyltransferase.
• Pharmaceutical Development: Used as a precursor or starting material in the synthesis of novel sphingolipid-based drug candidates targeting metabolic disorders, cancer, and inflammatory diseases.
• Lipidomics & Metabolomics: An essential internal or external standard for the mass spectrometry-based quantification and profiling of sphingolipids and their metabolites in biological samples.
• Enzyme Assays: Employed as a substrate or inhibitor in in vitro enzymatic assays to study the kinetics and function of enzymes involved in sphingolipid metabolism.
• Cell Signaling Studies: Utilized to modulate cellular levels of sphinganine and related metabolites to elucidate their role in apoptosis, proliferation, and stress responses.

Basic Information

Product Name	3-Keto Sphinganine (D12:0) (Hydrochloride)
CAS No.	1823032-02-5
Molecular Formula	C24H48NO3 • HCl
Molecular Weight	442.11 g/mol (free base: 406.65 g/mol)
Synonyms	3-Ketodihydrosphingosine (Dodecanoyl) Hydrochloride; 3-Ketosphinganine (N-Dodecanoyl) HCl; (2S,3R)-2-Amino-3-hydroxyoctadecan-1-one (Dodecanoyl) Hydrochloride; D-erythro-3-Ketosphinganine (C12:0) HCl; N-Dodecanoyl-3-ketosphinganine Hydrochloride; 3-Oxosphinganine (D12:0) HCl; Sphingolipid Intermediate KDS (C12) HCl
EINECS	Contact for details

Quality Control

Our 3-Keto Sphinganine (D12:0) (Hydrochloride) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.