Description

(R)-1-(Pyrimidin-2-Yl)Pyrrolidine-2-Carboxylic Acid is a high-purity chiral building block and intermediate of significant importance in modern pharmaceutical research and development. Its core value lies in its role as a key synthon for constructing complex molecules with specific stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs). This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for applications in drug discovery and synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in oncology, neurology, and antiviral research.
• Asymmetric Synthesis: Used as a precursor or ligand in catalytic asymmetric reactions to introduce stereogenic centers with high enantiomeric purity.
• Protease Inhibitor Development: Serves as a core scaffold or side chain in the design and synthesis of protease inhibitors due to its carboxylic acid and heterocyclic structure.
• Chemical Biology & Probe Design: Incorporated into molecular probes and tool compounds for studying biological targets and pathways.
• Peptidomimetics: Utilized in the construction of peptidomimetic structures to enhance metabolic stability and bioavailability of peptide-based therapeutics.
• Academic & Contract Research: Employed in academic laboratories and CROs (Contract Research Organizations) for exploratory chemistry and method development projects.

Basic Information

Product Name	(R)-1-(Pyrimidin-2-Yl)Pyrrolidine-2-Carboxylic Acid
CAS No.	1821832-73-8
Molecular Formula	C9H11N3O2
Molecular Weight	193.20 g/mol
Synonyms	(R)-1-(2-Pyrimidinyl)-2-pyrrolidinecarboxylic Acid; (R)-1-(Pyrimidin-2-yl)pyrrolidine-2-carboxylic acid; (2R)-1-Pyrimidin-2-ylpyrrolidine-2-carboxylic acid; Pyrrolidine-2-carboxylic acid, 1-(2-pyrimidinyl)-, (R)-; (R)-PCA Pyrimidine Derivative; (R)-Proline Pyrimidine Derivative; (R)-N-(Pyrimidin-2-yl)proline
EINECS	Contact for details

Quality Control

Our (R)-1-(Pyrimidin-2-Yl)Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.