Description

1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[4-[[4-(Trifluoromethyl)Phenyl]Methoxy]Phenyl]- is a high-value, organoboron building block featuring a pinacol boronic ester group and a trifluoromethyl-substituted aromatic ether. This compound is crucial for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex biaryl architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl motifs and trifluoromethyl groups.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the unique properties of the CF3 group enhance biological activity.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and semiconductors, via palladium-catalyzed coupling.
• Ligand and Catalyst Development: Employed in the synthesis of sophisticated ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying biological systems and mechanisms of action.
• Scale-up Process Chemistry: A reliable coupling partner for the pilot-plant and commercial-scale manufacturing of complex organic molecules.

Basic Information

Item	Details
Product Name	1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[4-[[4-(Trifluoromethyl)Phenyl]Methoxy]Phenyl]-
CAS No.	1813554-40-3
Molecular Formula	C20H22BF3O3
Molecular Weight	378.20 g/mol
Synonyms	[4-[[4-(Trifluoromethyl)phenoxy]phenyl]boronic acid pinacol ester; 4-(4-(Trifluoromethyl)phenoxy)phenylboronic acid pinacol ester; 2-[4-[[4-(Trifluoromethyl)Phenyl]Methoxy]Phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-ol, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, derivative; Pinacol [4-[[4-(trifluoromethyl)phenyl]oxy]phenyl]boronate; B-[4-[[4-(Trifluoromethyl)phenyl]oxy]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of our 1,3,2-Dioxaborolane intermediate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the exacting standards required for sensitive cross-coupling reactions. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant techniques is supplied with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent hydrolysis of the boronic ester functionality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.