Description

(1S,2S)-2-(Methoxymethyl)Cyclobutan-1-Amine Hydrochloride is a high-purity, chiral cyclobutane derivative, serving as a critical building block in modern organic synthesis. Its value lies in providing a structurally constrained, enantiomerically pure amine scaffold essential for constructing complex molecules with defined stereochemistry. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of new active pharmaceutical ingredients (APIs), particularly in areas requiring rigid, small-ring frameworks.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including antiviral and central nervous system (CNS) drugs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or resolving agent in stereoselective chemical transformations to control the three-dimensional architecture of target molecules.
• Ligand and Catalyst Development: Used as a precursor for synthesizing novel chiral ligands and organocatalysts for use in enantioselective catalysis.
• Peptidomimetics and Bioisosteres: Incorporated into peptide analogs and bioisosteric replacements where the cyclobutane ring mimics specific structural motifs to modulate biological activity and metabolic stability.
• Agrochemical Research: Investigated as a building block for creating new, stereochemically defined active ingredients in crop protection science.
• Material Science: Potential monomer or precursor for specialty polymers and advanced materials requiring specific chiral centers.

Basic Information

Product Name	(1S,2S)-2-(Methoxymethyl)Cyclobutan-1-Amine Hydrochloride
CAS No.	1807937-89-8
Molecular Formula	C6H14ClNO
Molecular Weight	151.63 g/mol
Synonyms	(1S,2S)-2-(Methoxymethyl)cyclobutan-1-amine hydrochloride; (1S,2S)-2-(Methoxymethyl)cyclobutanamine hydrochloride; (1S,2S)-2-(Methoxy-methyl)cyclobutan-1-amine HCl; (1S,2S)-2-(Methoxymethyl)-1-aminocyclobutane hydrochloride; trans-2-(Methoxymethyl)cyclobutan-1-amine hydrochloride; (1S,2S)-Aminocyclobutane derivative hydrochloride; (1S,2S)-Methoxymethylcyclobutylamine HCl
EINECS	Contact for details

Quality Control

Our (1S,2S)-2-(Methoxymethyl)Cyclobutan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.