Description

5-Bromo-2-Fluoro-4-Iodo-Benzoic Acid is a high-purity, multi-halogenated benzoic acid derivative designed for advanced synthetic chemistry. This compound serves as a versatile and critical building block for constructing complex molecular architectures, particularly in pharmaceutical discovery and materials science. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and pesticides, where the halogen pattern can influence bioactivity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating sophisticated ligands in transition metal catalysis and organocatalysis due to its halogen handles for further functionalization.
• Material Science Precursor: Employed in the synthesis of organic electronic materials, such as semiconductors and liquid crystals, where halogen atoms tune electronic properties.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Buchwald-Hartwig) thanks to its bromo and iodo substituents.
• Fluorine Chemistry Building Block: The fluorine atom makes it valuable for creating compounds with enhanced metabolic stability, bioavailability, and membrane permeability in drug design.

Basic Information

Product Name	5-Bromo-2-Fluoro-4-Iodo-Benzoic Acid
CAS No.	1807757-08-9
Molecular Formula	C7H3BrFIO2
Molecular Weight	344.90 g/mol
Synonyms	4-Iodo-5-bromo-2-fluorobenzoic acid; 2-Fluoro-4-iodo-5-bromobenzoic acid; Benzoic acid, 5-bromo-2-fluoro-4-iodo-; 5-Bromo-2-fluoro-4-iodobenzoic acid; 1807757-08-9; 4-Iodo-5-bromo-2-fluoro-benzoic acid
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Fluoro-4-Iodo-Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.