Description

2-Amino-3-Chloro-5-Trifluoromethyl-Benzoic Acid Methyl Ester is a high-purity, multi-functional chemical intermediate of significant importance in advanced organic synthesis. Its molecular structure, featuring amino, chloro, and trifluoromethyl substituents, makes it a versatile building block for constructing complex, biologically active molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals and organic semiconductors, due to its electron-withdrawing substituents.
• Custom Synthesis and Contract Manufacturing: A critical raw material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Amino-3-Chloro-5-Trifluoromethyl-Benzoic Acid Methyl Ester
CAS No.	1806927-85-4
Molecular Formula	C9H7ClF3NO2
Molecular Weight	253.61 g/mol
Synonyms	Methyl 2-Amino-3-Chloro-5-(trifluoromethyl)benzoate; Benzoic acid, 2-amino-3-chloro-5-(trifluoromethyl)-, methyl ester; 2-Amino-3-chloro-α,α,α-trifluoro-p-toluic acid methyl ester; 3-Chloro-2-amino-5-trifluoromethylbenzoic acid methyl ester; Methyl 3-chloro-2-amino-5-trifluoromethylbenzoate
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Chloro-5-Trifluoromethyl-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.