Description

Methyl 4-Chloro-2-Fluoro-6-Methylbenzoate is a high-purity fluorinated benzoate ester derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a versatile, functionalized aromatic scaffold for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists in fine chemical, pharmaceutical, and crop protection industries who require reliable, high-quality building blocks for drug discovery and active ingredient development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine substituents enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution to introduce functionalized benzoate groups into complex molecular architectures.
• Chemical Research & Development: A valuable tool for medicinal chemistry and process chemistry R&D teams exploring new chemical entities and optimizing synthetic routes.
• Dye & Pigment Intermediate: Potential use in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	Methyl 4-Chloro-2-Fluoro-6-Methylbenzoate
CAS No.	1805525-21-6
Molecular Formula	C9H8ClFO2
Molecular Weight	202.61 g/mol
Synonyms	4-Chloro-2-fluoro-6-methylbenzoic acid methyl ester; Methyl 4-chloro-2-fluoro-6-methylbenzoate; Benzoic acid, 4-chloro-2-fluoro-6-methyl-, methyl ester; 2-Fluoro-4-chloro-6-methylbenzoic acid methyl ester; Methyl 2-fluoro-4-chloro-6-methylbenzoate; 1805525-21-6; MFCD31812862
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Chloro-2-Fluoro-6-Methylbenzoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and IR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.