Description

Methyl 2-Bromo-3,6-Difluorobenzoate is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials. The specific substitution pattern on the benzoate ring makes it a versatile precursor for introducing halogenated and fluorinated motifs into target structures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where the difluoro and bromo substituents modulate biological activity.
• Material Science Research: Serves as a monomer or precursor for synthesizing specialty polymers and liquid crystals with unique electronic or optical properties.
• Chemical Biology Probes: Employed in the creation of fluorinated molecular probes and tags for studying biological mechanisms and diagnostic applications.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form biaryl structures common in many functional materials.

Basic Information

Product Name	Methyl 2-Bromo-3,6-Difluorobenzoate
CAS No.	1805523-44-7
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	2-Bromo-3,6-difluorobenzoic acid methyl ester; Methyl 2-bromo-3,6-difluorobenzoate; Benzoic acid, 2-bromo-3,6-difluoro-, methyl ester; 3,6-Difluoro-2-bromobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Bromo-3,6-Difluorobenzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay and impurity profiles. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.