Description

Methyl 2-Bromo-3,4-Difluorobenzoate is a high-purity, multi-functional aromatic ester building block essential for advanced organic synthesis. Its core value lies in its precise bromo- and difluoro-substitution pattern, which enables efficient derivatization and the introduction of key functional groups into target molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex intermediates, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially those requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluorobenzene moiety is a critical structural element.
• Material Science Research: Serves as a precursor for synthesizing specialty monomers, ligands for catalysis, and advanced polymers with specific electronic properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and agrochemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized fluorinated intermediates.

Basic Information

Product Name	Methyl 2-Bromo-3,4-Difluorobenzoate
CAS No.	1805523-36-7
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	2-Bromo-3,4-difluorobenzoic acid methyl ester; Methyl 2-bromo-3,4-difluorobenzoate; Benzoic acid, 2-bromo-3,4-difluoro-, methyl ester; 3,4-Difluoro-2-bromobenzoic acid methyl ester; Methyl 3,4-difluoro-2-bromobenzoate; 2-Bromo-3,4-difluorobenzoic acid, methyl ester; Methyl ester of 2-bromo-3,4-difluorobenzoic acid
EINECS	Contact for details

Quality Control

Every batch of Methyl 2-Bromo-3,4-Difluorobenzoate is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical synthesis work. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and are standard for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.