Description

4-Bromo-2,5-Bis(trifluoromethyl)benzoic Acid is a highly functionalized benzoic acid derivative distinguished by its bromine and trifluoromethyl substituents. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis, valued for its ability to impart unique electronic and steric properties to target molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the trifluoromethyl groups enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a building block for creating sophisticated ligands in transition metal catalysis and organocatalysis.
• Material Science: Incorporated into the design of specialty polymers, liquid crystals, and organic electronic materials to modify solubility and electronic characteristics.
• Chemical Research: Employed in academic and industrial R&D for exploring new reaction pathways and synthesizing fluorinated aromatic compounds.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals for client projects.

Basic Information

Product Name	4-Bromo-2,5-Bis(trifluoromethyl)benzoic Acid
CAS No.	1805511-32-3
Molecular Formula	C9H3BrF6O2
Molecular Weight	337.02 g/mol
Synonyms	4-Bromo-2,5-bis(trifluoromethyl)benzoic acid; 2,5-Bis(trifluoromethyl)-4-bromobenzoic acid; Benzoic acid, 4-bromo-2,5-bis(trifluoromethyl)-; 1805511-32-3; 4-Bromo-α,α,α,α',α',α'-hexafluoro-2,5-xylene-α-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 4-Bromo-2,5-Bis(trifluoromethyl)benzoic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. The compound is compatible with strong acid/organic solvent environments but should be handled with standard laboratory precautions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.