Description

Methyl 4-Bromo-2-Fluoro-3-Nitrobenzoate is a high-purity, multi-functional aromatic ester building block designed for advanced chemical synthesis. This compound matters as a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique halogen and nitro substitution pattern enables precise structural modifications. It is primarily needed by R&D chemists and process development scientists in pharmaceutical, agrochemical, and advanced material industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing fluorinated and halogenated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated nitroaromatic structure.
• Material Science Research: Acts as a building block for creating specialized polymers, liquid crystals, or organic electronic materials requiring specific halogenated aromatic monomers.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the presence of the bromo substituent.
• Nitro Group Functionalization: The nitro group provides a handle for further reduction to amines or other transformations, enabling diverse synthetic pathways.
• Fluorine Chemistry Studies: Utilized in medicinal chemistry to study the effects of fluorine introduction on bioactivity, metabolism, and physicochemical properties of lead compounds.

Basic Information

Product Name	Methyl 4-Bromo-2-Fluoro-3-Nitrobenzoate
CAS No.	1805190-07-1
Molecular Formula	C8H5BrFNO4
Molecular Weight	278.03 g/mol
Synonyms	4-Bromo-2-fluoro-3-nitrobenzoic acid methyl ester; Methyl 4-bromo-2-fluoro-3-nitrobenzoate; Benzoic acid, 4-bromo-2-fluoro-3-nitro-, methyl ester; Methyl ester of 4-bromo-2-fluoro-3-nitrobenzoic acid; 4-Bromo-2-fluoro-3-nitro-methylbenzoate; 1805190-07-1; CAS 1805190-07-1
EINECS	Contact for details

Quality Control

Our Methyl 4-Bromo-2-Fluoro-3-Nitrobenzoate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC Area %)	≥98.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.