Description

Methyl 2,5-Difluoro-6-Nitrobenzoate is a high-purity fluorinated aromatic building block, essential for advanced organic synthesis. Its value lies in the strategic placement of fluorine and nitro groups, which are critical for modulating the electronic and steric properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system or possessing anti-inflammatory properties.
• Agrochemical Synthesis: Used in the development of new herbicides and pesticides, where the difluoro-nitro substitution pattern can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic electronic materials, contributing to improved charge transport and emission characteristics.
• Cross-Coupling Reactions: The ester and nitro groups provide handles for further functionalization via palladium-catalyzed reactions like Suzuki or Stille couplings.
• Fluorine Chemistry Studies: An important reagent for investigating structure-activity relationships (SAR) in medicinal chemistry due to its distinct fluorine substitution pattern.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of complex, fluorinated target molecules under cGMP conditions.

Basic Information

Product Name	Methyl 2,5-Difluoro-6-Nitrobenzoate
CAS No.	1803730-28-0
Molecular Formula	C8H5F2NO4
Molecular Weight	217.13 g/mol
Synonyms	2,5-Difluoro-6-nitrobenzoic acid methyl ester; Methyl 2,5-difluoro-6-nitrobenzoate; Benzoic acid, 2,5-difluoro-6-nitro-, methyl ester; Methyl 2,5-difluoro-6-nitrobenzenecarboxylate; 6-Nitro-2,5-difluorobenzoic acid methyl ester; Methyl 6-nitro-2,5-difluorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 2,5-Difluoro-6-Nitrobenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound should be handled in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.