Description

([13C6]Leu5)-Ghrelin (Human) (H-7252.0500) is a stable isotope-labeled analog of the human appetite-regulating hormone ghrelin, specifically modified with six carbon-13 atoms at the leucine-5 position. This compound is an essential internal standard for the precise quantification of endogenous ghrelin levels in complex biological matrices using mass spectrometry. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and academic institutions engaged in metabolic disorder studies, obesity research, and endocrinology.

Application

• Quantitative Mass Spectrometry: Serves as a critical internal standard for Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) bioanalysis of ghrelin in plasma, serum, and tissue samples.
• Metabolic Research: Enables accurate pharmacokinetic (PK) and pharmacodynamic (PD) studies in preclinical and clinical trials for drugs targeting the ghrelin pathway.
• Biomarker Validation: Used in the development and validation of robust clinical assays to measure ghrelin as a biomarker for metabolic syndromes.
• Endocrinology Studies: Facilitates precise research into the role of ghrelin in hunger signaling, growth hormone secretion, and energy homeostasis.
• Quality Control in Peptide Synthesis: Acts as a reference material for the quality assessment of synthesized ghrelin peptides and related analogs.

Basic Information

Item	Detail
Product Name	([13C6]Leu5)-Ghrelin (Human) (H-7252.0500)
CAS No.	1802078-40-5
Molecular Formula	C147H245N43O42 (with 13C6 label)
Molecular Weight	~3324.8 g/mol (labeled form)
Synonyms	Ghrelin (human) [13C6]Leu5-labeled; Stable Isotope-Labeled Ghrelin; [13C6]-Leu5-Ghrelin; Ghrelin IS (Internal Standard); H-7252.0500; Appetite-regulating hormone internal standard; Human Ghrelin (1-28), [13C6]Leu5-; Des-acyl ghrelin analog standard
EINECS	Contact for details

Quality Control

Every batch of ([13C6]Leu5)-Ghrelin (Human) is manufactured and analyzed under strict quality protocols to ensure identity, purity, and isotopic enrichment suitable for sensitive bioanalytical applications. Our quality commitment includes comprehensive characterization by HPLC, MS, and NMR to verify chemical and isotopic purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated at -80°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Molecular ion peak conforms
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 98 atom % 13C
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, acetonitrile/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.