Description

H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-[13C6]Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-Oh is a high-purity, isotopically labeled peptide analog of glucagon-like peptide-1 (GLP-1), a critical hormone in metabolic regulation. This compound is specifically engineered with a stable carbon-13 ([13C6]) isotope label on the leucine residue, making it an indispensable tool for advanced quantitative mass spectrometry and pharmacokinetic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on diabetes, obesity research, and the development of next-generation peptide therapeutics.

Application

• Internal Standard for LC-MS/MS Quantification: Serves as a critical, non-interfering reference standard for the precise bioanalysis of GLP-1 and its analogs in complex biological matrices like plasma and serum.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) for GLP-1 based therapies.
• Metabolic Pathway Tracing: The [13C6] label allows researchers to trace and elucidate metabolic pathways and degradation products of therapeutic peptides.
• Method Development and Validation: Used as a certified reference material to develop, optimize, and validate robust analytical methods in compliance with GLP and FDA guidelines.
• Quality Control in Peptide Manufacturing: Acts as a high-purity benchmark for assessing the identity, purity, and potency of GLP-1 analog active pharmaceutical ingredients (APIs).
• Proteomics and Biomarker Discovery Research: Facilitates targeted proteomic studies aimed at discovering and validating peptide biomarkers related to metabolic diseases.

Basic Information

Product Name	H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-[13C6]Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-Oh
CAS No.	1802078-39-2
Molecular Formula	C149H226N44O49S (with [13C6] isotopic enrichment)
Molecular Weight	~3357.7 g/mol (average isotopic composition)
Synonyms	GLP-1 (7-36) amide, [13C6]Leu14-labeled; [13C6]Leu14-GLP-1 (7-36)-NH2; Glucagon-like peptide-1 (7-36) amide, Leu-14-[13C6] labeled; Isotopically labeled GLP-1 internal standard; [13C6]-L-Leucine14 GLP-1 amide; GLP-1 I.S. for LC-MS; H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu([13C6])-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2
EINECS	Contact for details

Quality Control

Every batch of our isotopically labeled peptides is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Purity and identity are confirmed via HPLC, MS (ESI/TOF), and NMR to ensure the specified isotopic enrichment and chemical integrity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, isotopic purity, water content, and peptide content. Our production aligns with standards suitable for GLP and research use.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Under these conditions, the product is typically stable for at least 24 months.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum confirms molecular ion and sequence
Purity (HPLC)	≥ 95% (Area % at 214 nm)
Isotopic Purity ([13C6])	≥ 98 atom % 13C
Peptide Content (UV)	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.