Description

2-Chloro-4,5-Difluorophenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing complex difluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where specific halogenated biphenyl motifs are required for bioactivity.
• Material Science: Serves as a monomer or building block for creating advanced organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A versatile reagent for academic and industrial R&D labs exploring new synthetic pathways and novel compound libraries.
• Fine Chemical Production: Integral to the multi-step synthesis of complex fine chemicals and specialty compounds for various high-tech applications.

Basic Information

Product Name	2-Chloro-4,5-Difluorophenylboronic Acid
CAS No.	1801916-39-1
Molecular Formula	C6H4BClF2O2
Molecular Weight	191.36 g/mol
Synonyms	(2-Chloro-4,5-difluorophenyl)boronic acid; 2-Chloro-4,5-difluorobenzeneboronic acid; B-(2-Chloro-4,5-difluorophenyl)boronic acid; 1801916-39-1; 2-Chloro-4,5-difluoro phenyl boronic acid; Boronic acid, B-(2-chloro-4,5-difluorophenyl)-; 2-Cl-4,5-F2-PhB(OH)2
EINECS	Contact for details

Quality Control

Our 2-Chloro-4,5-Difluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance for sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.