Description

p-Coumaric Acid-D4 Sulfate is a high-purity, deuterium-labeled internal standard critical for advanced analytical quantification. This compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and other sophisticated bioanalytical techniques, ensuring unparalleled accuracy and reliability in trace-level analysis. It is an essential reagent for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and clinical diagnostics sectors who require precise measurement of p-coumaric acid and its metabolites in complex biological matrices.

Application

• Quantitative LC-MS/MS Analysis: Serves as a stable isotope-labeled internal standard for the accurate quantification of p-coumaric acid and its sulfate conjugates in pharmacokinetic and metabolomic studies.
• Biomedical Research: Used in investigating the bioavailability, metabolism, and pharmacokinetics of phenolic acids and polyphenolic compounds.
• Pharmaceutical Development: Critical for method development and validation in drug discovery pipelines involving natural product derivatives or phenolic acid-based therapeutics.
• Nutraceutical & Food Science: Enables precise analysis of bioactive compounds in functional foods, dietary supplements, and botanical extracts for quality assurance and standardization.
• Clinical Diagnostics: Facilitates the development of robust assays for biomarker discovery and validation related to oxidative stress, inflammation, and dietary exposure.
• Environmental & Agricultural Analysis: Applied in tracing the fate and metabolism of phenolic compounds in plants and environmental samples.

Basic Information

Product Name	p-Coumaric Acid-D4 Sulfate
CAS No.	1795140-39-4
Molecular Formula	C9D4H4O7S
Molecular Weight	260.24 g/mol (approx.)
Synonyms	4-Hydroxycinnamic Acid-d4 Sulfate; (E)-3-(4-Hydroxyphenyl)-2-propenoic Acid-d4 Sulfate; Deuterated p-Coumaric Acid Sulfate; p-Coumaric Acid-d4 Sulfate Potassium Salt (common salt form); 4-Coumaric Acid-D4 Sulfate; p-Coumaric Acid Sulfate-d4; [2,3,5,6-D4]-4-Hydroxycinnamic Acid Sulfate
EINECS	Contact for details

Quality Control

Every batch of p-Coumaric Acid-D4 Sulfate is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and isotopic enrichment. Our quality protocols are designed to meet the exacting standards of analytical reference material users. A detailed Certificate of Analysis (COA) is provided with each shipment, containing data for critical parameters including HPLC purity, isotopic purity (D-enrichment %), NMR confirmation, and mass spectrometry verification.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the product to equilibrate to room temperature in a dry environment before opening to prevent condensation. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.