Description

Di-tert-Butyl((2R,3R)-3-(tert-Butyl)-4-(Dimethylamino)-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)Phosphine Oxide is a sophisticated chiral organophosphorus compound characterized by its unique bicyclic oxaphosphole structure. This compound matters as a high-value specialty chemical intermediate and ligand precursor for advanced catalytic systems and pharmaceutical synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for developing novel synthetic methodologies and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex, biologically active molecules and potential APIs.
• Asymmetric Catalysis: Serves as a precursor for novel chiral phosphine-phosphine oxide (P=O) ligands used in transition-metal catalyzed asymmetric reactions.
• Organocatalysis Research: Investigated as a potential organocatalyst or co-catalyst due to its Lewis basic phosphorus and nitrogen centers.
• Material Science: Used in the development of specialized polymers or functional materials where phosphorus-containing moieties impart specific properties.
• Agrochemical Synthesis: An intermediate in the research and development of new, high-performance crop protection agents.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis and new reaction discovery.

Basic Information

Item	Details
Product Name	Di-tert-Butyl((2R,3R)-3-(tert-Butyl)-4-(Dimethylamino)-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)Phosphine Oxide
CAS No.	1788085-47-1
Molecular Formula	C22H39N1O2P2
Molecular Weight	411.51 g/mol
Synonyms	(2R,3R)-2-(Di-tert-butylphosphinyl)-3-tert-butyl-4-(dimethylamino)-2,3-dihydro-1,3-benzoxaphosphole 2-oxide; (2R,3R)-3-(tert-Butyl)-4-(dimethylamino)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl-di-tert-butylphosphine oxide; Chiral Oxaphosphole Phosphine Oxide; DTBPO Ligand Precursor; (R,R)-Di-tert-butyl((3-(tert-butyl)-4-(dimethylamino)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl))phosphine oxide
EINECS	Contact for details

Quality Control

Our production of Di-tert-Butyl((2R,3R)-3-(tert-Butyl)-4-(Dimethylamino)-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)Phosphine Oxide adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for sensitive synthetic applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container for extended periods to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.