Description

2-(3-Bromo-4-Fluorophenyl)-2,2-Difluoroacetic Acid is a high-purity, multi-functional fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique molecular architecture, which incorporates both bromo and difluoroacetate functional groups on a phenyl ring, enabling precise structural modifications in target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Serves as a versatile precursor for developing novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Used in the synthesis of specialty monomers and polymers, including liquid crystals and advanced fluorinated materials with unique electronic or surface properties.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl systems.
• Fluorination Chemistry: The difluoroacetic acid moiety provides a handle for introducing CF2 groups, a critical motif in medicinal chemistry for modulating metabolic stability and lipophilicity.
• Custom Synthesis & Contract Manufacturing: An important starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Product Name	2-(3-Bromo-4-Fluorophenyl)-2,2-Difluoroacetic Acid
CAS No.	1785259-60-0
Molecular Formula	C8H4BrF3O2
Molecular Weight	269.02 g/mol
Synonyms	2-(3-Bromo-4-fluorophenyl)-2,2-difluoroacetic acid; 3-Bromo-4-fluoro-alpha,α-difluorobenzeneacetic acid; 2,2-Difluoro-2-(3-bromo-4-fluorophenyl)acetic acid; (3-Bromo-4-fluorophenyl)difluoroacetic acid; α,α-Difluoro-3-bromo-4-fluorophenylacetic acid; 1785259-60-0; 2-(3-Bromo-4-fluorophenyl)-2,2-difluoroethanoic acid
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Bromo-4-Fluorophenyl)-2,2-Difluoroacetic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are developed to meet the exacting standards required for research and commercial-scale synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.