Description

(4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylsulfonyl)-3-Fluorophenyl)Boronic Acid is a sophisticated organoboron building block featuring a unique spirocyclic sulfonamide-protected amine group. This compound is critically important as a key intermediate in modern pharmaceutical research, particularly in the synthesis of complex small molecule drug candidates. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for applications in drug discovery and development.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A pivotal reagent for forming carbon-carbon bonds in the synthesis of biaryl and heterobiaryl structures, a common motif in active pharmaceutical ingredients (APIs).
• Medicinal Chemistry & Drug Discovery: Serves as a versatile building block for constructing libraries of novel compounds for high-throughput screening against biological targets.
• Process Chemistry & API Development: Used in the scale-up and optimization of synthetic routes for potential new drugs, leveraging its stability and reactivity.
• Synthesis of Proteolysis Targeting Chimeras (PROTACs): The boronic acid group and complex structure make it suitable for constructing linkers or warheads in targeted protein degradation platforms.
• Material Science Research: Potential use in creating novel organic electronic materials or metal-organic frameworks (MOFs) due to its conjugated system and functional handles.

Basic Information

Item	Detail
Product Name	(4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylsulfonyl)-3-Fluorophenyl)Boronic Acid
CAS No.	1704096-52-5
Molecular Formula	C15H19BFNO5S
Molecular Weight	355.19 g/mol
Synonyms	3-Fluoro-4-(1,4-dioxa-8-azaspiro[4.5]decane-8-sulfonyl)benzeneboronic acid; (3-Fluoro-4-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)sulfonyl)phenyl)boronic acid; 4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-3-fluorobenzeneboronic acid; B-(4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-3-fluorophenyl)boronic acid; 1704096-52-5; 8-(4-Borono-2-fluorophenyl)sulfonyl-1,4-dioxa-8-azaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our (4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylsulfonyl)-3-Fluorophenyl)Boronic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical: 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.