Description

(3-Fluoro-5-(Piperazin-1-Ylmethyl)Phenyl)Boronic Acid Hydrochloride is a high-value, multifunctional boronic acid derivative essential for modern synthetic chemistry. Its core value proposition lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a piperazine moiety that serves as a versatile pharmacophore and linker. This compound is critically needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) therapeutics. Its structure makes it a key intermediate for constructing complex, drug-like molecules with enhanced solubility and binding properties.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of targeted small-molecule drugs, especially kinase inhibitors and receptor modulators.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functional group enables efficient palladium-catalyzed carbon-carbon bond formation to create biaryl structures common in advanced materials and agrochemicals.
• Proteolysis Targeting Chimera (PROTAC) Development: The piperazine linker is instrumental in constructing bifunctional molecules that recruit E3 ubiquitin ligases for targeted protein degradation.
• Chemical Biology & Probe Development: Used to create molecular probes for studying enzyme function and protein-protein interactions within biological systems.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of novel organic electronic materials and sensors.
• Library Synthesis for Drug Discovery: Enables high-throughput parallel synthesis to generate diverse compound libraries for screening against novel biological targets.

Basic Information

Item	Detail
Product Name	(3-Fluoro-5-(Piperazin-1-Ylmethyl)Phenyl)Boronic Acid Hydrochloride
CAS No.	1704096-40-1
Molecular Formula	C11H17BFN2O2 • HCl
Molecular Weight	270.54 g/mol (Free base) / 306.99 g/mol (HCl salt)
Synonyms	3-Fluoro-5-(piperazin-1-ylmethyl)phenylboronic acid hydrochloride; (3-Fluoro-5-((piperazin-1-yl)methyl)phenyl)boronic acid hydrochloride; B-[3-Fluoro-5-(1-piperazinylmethyl)phenyl]boronic acid hydrochloride; 5-(Piperazin-1-ylmethyl)-3-fluorobenzeneboronic acid HCl; 3-Fluoro-5-(piperazin-1-ylmethyl)benzeneboronic acid hydrochloride salt; 1704096-40-1 (CAS Index Name); Boronic acid, B-[3-fluoro-5-[(1-piperazinyl)methyl]phenyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our (3-Fluoro-5-(Piperazin-1-Ylmethyl)Phenyl)Boronic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) are provided with each shipment, detailing results from HPLC, NMR, and mass spectrometry. We support compliance with ICH Q7 guidelines and can supply material suitable for use under cGMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container for extended periods to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.