Description

(4-((4-((tert-Butyldimethylsilyl)Oxy)Piperidin-1-Yl)Sulfonyl)-2-Fluorophenyl)Boronic Acid is a sophisticated, multi-functional organoboron building block designed for advanced synthetic chemistry. Its value lies in the strategic combination of a boronic acid group for Suzuki-Miyaura cross-coupling, a sulfonamide linker, and a protected piperidine moiety, enabling the construction of complex, pharmaceutically relevant scaffolds. This high-purity intermediate is essential for researchers and process chemists in pharmaceutical R&D and agrochemical discovery programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and protease inhibitor research.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functionality enables efficient carbon-carbon bond formation with aryl/heteroaryl halides to create complex biaryl structures.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in constructing linker-warhead conjugates due to its sulfonamide group and orthogonal reactivity.
• Agrochemical Synthesis: Serves as a precursor for advanced active ingredients requiring sulfonamide and fluorinated aromatic motifs.
• Material Science Research: Potential monomer or cross-linker for creating functional polymers with specific ligand-binding properties.
• Chemical Biology Probes: Useful for synthesizing activity-based probes or affinity labels to study enzyme function.

Basic Information

Product Name	(4-((4-((tert-Butyldimethylsilyl)Oxy)Piperidin-1-Yl)Sulfonyl)-2-Fluorophenyl)Boronic Acid
CAS No.	1704096-28-5
Molecular Formula	C₁₇H₂₈BFNO₄SSi
Molecular Weight	399.38 g/mol
Synonyms	(4-((4-((tert-Butyldimethylsilyl)oxy)piperidin-1-yl)sulfonyl)-2-fluorophenyl)boronic acid; 2-Fluoro-4-((4-((tert-butyldimethylsilyl)oxy)piperidin-1-yl)sulfonyl)phenylboronic acid; 4-(N-[4-(tert-Butyldimethylsilyloxy)piperidin-1-yl]sulfonyl)-2-fluorobenzeneboronic acid; B-[4-[[4-[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-piperidinyl]sulfonyl]-2-fluorophenyl]boronic acid; TBDMS-protected piperidine sulfonyl fluorophenyl boronic acid; CAS 1704096-28-5; 1704096-28-5
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized by HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen). This compound is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.