Description

(4-(n-(tert-Butyl)Sulfamoyl)-3-Fluorophenyl)Boronic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique sulfamoyl-boronic acid bifunctional structure. This compound is critical for modern drug discovery, particularly in the synthesis of complex small-molecule therapeutics via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in developing novel enzyme inhibitors and targeted therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of protease and kinase inhibitors for oncology and metabolic disease research.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid reagent for constructing biaryl and heterobiaryl scaffolds central to many active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize drug candidates.
• Chemical Biology Probes: Employed in the development of activity-based probes for studying enzyme function and target engagement.
• Agrochemical Synthesis: Potential intermediate in creating novel herbicides and fungicides with specific modes of action.
• Material Science: Exploration into organic electronic materials and metal-organic frameworks (MOFs) due to its functional handles.

Basic Information

Product Name	(4-(n-(tert-Butyl)Sulfamoyl)-3-Fluorophenyl)Boronic Acid
CAS No.	1704095-87-3
Molecular Formula	C10H15BFNO4S
Molecular Weight	287.11 g/mol
Synonyms	[4-[[(1,1-Dimethylethyl)amino]sulfonyl]-3-fluorophenyl]boronic acid; (4-(N-tert-Butylsulfamoyl)-3-fluorophenyl)boronic acid; 3-Fluoro-4-(N-tert-butylsulfamoyl)phenylboronic acid; B-[4-[(tert-Butylamino)sulfonyl]-3-fluorophenyl]boronic acid; Boronic acid, B-[4-[[(1,1-dimethylethyl)amino]sulfonyl]-3-fluorophenyl]-; 1704095-87-3; Tert-butyl(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfamide (Pinacol ester precursor)
EINECS	Contact for details

Quality Control

Every batch of (4-(n-(tert-Butyl)Sulfamoyl)-3-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and LC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity. For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR/Titration)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.