Description

(4-(2-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Yl)Ethoxy)-3-Fluorophenyl)Boronic Acid is a sophisticated boronic acid derivative featuring a spirocyclic acetal-protected amino group, making it a valuable building block for modern synthetic chemistry. Its core value lies in its dual functionality, serving as both a Suzuki-Miyaura cross-coupling partner and a precursor for introducing a protected amine moiety into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery programs.
• Suzuki-Miyaura Cross-Coupling: Used as an organoboron reagent in palladium-catalyzed reactions to form biaryl and heterobiaryl carbon-carbon bonds, a cornerstone of medicinal chemistry.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed in the construction of linkers and warhead components for targeted protein degradation therapeutics.
• Agrochemical Synthesis: Intermediate in creating novel herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Research: Precursor for synthesizing functionalized polymers or organic electronic materials requiring specific amine and aryl functionalities.
• Chemical Biology Probes: Useful for creating tagged molecules or affinity probes to study biological pathways and protein interactions.

Basic Information

Product Name	(4-(2-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Yl)Ethoxy)-3-Fluorophenyl)Boronic Acid
CAS No.	1704082-85-8
Molecular Formula	C19H28BFNO5
Molecular Weight	395.24 g/mol
Synonyms	[4-[2-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)ethoxy]-3-fluorophenyl]boronic acid; 3-Fluoro-4-[2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)ethoxy]benzeneboronic acid; B-[4-[2-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)ethoxy]-3-fluorophenyl]boronic acid; (3-Fluoro-4-(2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethoxy)phenyl)boronic acid; Boronic acid, B-[4-[2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)ethoxy]-3-fluorophenyl]-; 1704082-85-8; Spirocyclic Acetal-Protected Aminophenyl Boronic Acid Ester
EINECS	Contact for details

Quality Control

Our (4-(2-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Yl)Ethoxy)-3-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container sealed under an inert atmosphere if long-term storage is required.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.