Description

4-(2-(tert-Butoxycarbonyl(Cyclopropyl)Amino)Ethoxy)-3-Fluorophenylboronic Acid is a sophisticated boronic acid derivative featuring a protected cyclopropylaminoethoxy linker and a fluorine substituent on the aromatic ring. This compound matters as a critical, high-value building block in modern pharmaceutical discovery, enabling the synthesis of complex molecules through reliable Suzuki-Miyaura cross-coupling reactions. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for constructing novel drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for small molecule therapeutics targeting various disease pathways.
• Suzuki-Miyaura Cross-Coupling: Serves as the boronic acid coupling partner for forming carbon-carbon bonds with aryl/heteroaryl halides, a cornerstone reaction in medicinal chemistry.
• Protease Inhibitor Research: Used in the development of protease inhibitor libraries, leveraging the boronic acid moiety's ability to interact with enzyme active sites.
• Bioconjugation & ADC Development: The functional groups allow for potential use in bioconjugation strategies for Antibody-Drug Conjugates (ADCs) and other targeted therapies.
• Agrochemical Synthesis: Employed in the research and development of advanced agrochemicals, where the fluorophenyl and boronic acid groups contribute to bioactivity.
• Material Science & OLED Research: Acts as a monomer or intermediate for creating novel organic electronic materials and emissive layers in OLED devices.

Basic Information

Product Name	4-(2-(tert-Butoxycarbonyl(Cyclopropyl)Amino)Ethoxy)-3-Fluorophenylboronic Acid
CAS No.	1704064-17-4
Molecular Formula	C₁₆H₂₁BFNO₅
Molecular Weight	337.16 g/mol
Synonyms	[4-[2-[Cyclopropyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]ethoxy]-3-fluorophenyl]boronic acid; B-[4-[2-[Cyclopropyl-[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-3-fluorophenyl]boronic acid; 3-Fluoro-4-[2-[N-(tert-butoxycarbonyl)cyclopropylamino]ethoxy]benzeneboronic acid; Boc-Cyclopropylaminoethoxy-FluoroPhenylBoroninc Acid; CAS 1704064-17-4; 4-(2-(N-Boc-cyclopropylamino)ethoxy)-3-fluorobenzeneboronic acid; tert-Butyl N-cyclopropyl-N-[2-(4-borono-2-fluoro-phenoxy)ethyl]carbamate
EINECS	Contact for details

Quality Control

Our 4-(2-(tert-Butoxycarbonyl(Cyclopropyl)Amino)Ethoxy)-3-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and pre-clinical standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.