Description

4-(2-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Ethoxy)-3-Fluorophenylboronic Acid CAS NO 1704064-14-1 is a sophisticated boronic acid derivative featuring a protected piperazine moiety, designed for advanced synthetic applications. This compound is a critical building block in modern pharmaceutical research, enabling the precise construction of complex molecules through reliable cross-coupling reactions. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for targeted therapies.
• Suzuki-Miyaura Cross-Coupling: Essential boron reagent for constructing biaryl and heterobiaryl scaffolds in drug discovery.
• Protease & Kinase Inhibitor Development: Used to create complex molecular architectures targeting specific enzymes.
• Peptidomimetic Synthesis: Incorporates the piperazine-Boc motif into peptide-like structures to enhance drug-like properties.
• Chemical Biology Probes: Serves as a versatile handle for labeling and studying biological systems.
• Process Chemistry & Scale-up: Supports route development from milligram to kilogram scale for clinical trial material production.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries.

Basic Information

Item	Details
Product Name	4-(2-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Ethoxy)-3-Fluorophenylboronic Acid
CAS No.	1704064-14-1
Molecular Formula	C₁₇H₂₆BFN₂O₄
Molecular Weight	364.21 g/mol
Synonyms	3-Fluoro-4-[2-[4-[(1,1-Dimethylethoxy)carbonyl]-1-piperazinyl]ethoxy]benzeneboronic Acid; BOC-Piperazine-PEG2-3-Fluoro-4-Boronic Acid; 4-(2-(4-Boc-Piperazin-1-yl)ethoxy)-3-fluorobenzeneboronic Acid; 3-Fluoro-4-(2-(4-(tert-butoxycarbonyl)piperazin-1-yl)ethoxy)phenylboronic Acid; 1704064-14-1; tert-Butyl 4-[2-(4-borono-2-fluorophenoxy)ethyl]piperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 4-(2-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Ethoxy)-3-Fluorophenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for each lot, and we support compliance with ICH Q7 guidelines and relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.