Description

4-(3-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Propoxy)-3-Fluorophenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern organic synthesis. Its value lies in its dual functionality, combining a protected piperazine moiety with a boronic acid group, enabling precise cross-coupling reactions and the construction of complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic acid functional group makes it an ideal partner for palladium-catalyzed cross-coupling, a fundamental reaction for forming carbon-carbon bonds in medicinal chemistry.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group protects the piperazine nitrogen, allowing for selective reactions elsewhere on the molecule before deprotection.
• Library Synthesis for Drug Discovery: Used in high-throughput and combinatorial chemistry to create diverse arrays of compounds for biological screening and structure-activity relationship (SAR) studies.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides that require complex amine-containing structures.
• Material Science Precursor: Potential use in synthesizing organic electronic materials or metal-organic frameworks (MOFs) where precise molecular geometry is required.

Basic Information

Product Name	4-(3-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Propoxy)-3-Fluorophenylboronic Acid
CAS No.	1704064-07-2
Molecular Formula	C18H28BFN2O4
Molecular Weight	366.24 g/mol
Synonyms	[4-[3-[4-[(2-Methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]propoxy]-3-fluorophenyl]boronic acid; 3-Fluoro-4-[3-[4-[(tert-butoxy)carbonyl]-1-piperazinyl]propoxy]benzeneboronic acid; 4-(3-(4-Boc-piperazin-1-yl)propoxy)-3-fluorobenzeneboronic acid; Boc-Piperazine-Propoxy-Fluoro-Phenylboronic Acid; CAS 1704064-07-2; 1704064-07-2
EINECS	Contact for details

Quality Control

Every batch of 4-(3-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Propoxy)-3-Fluorophenylboronic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity, meeting the stringent requirements for pharmaceutical R&D and cGMP intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.