Description

4-((tert-Butoxycarbonyl(Cyclopropyl)Amino)Methyl)-3-Fluorophenylboronic Acid is a sophisticated boronic acid derivative featuring a protected cyclopropylamine group and a fluorine substituent. This compound matters as a high-value building block in modern synthetic chemistry, enabling the precise construction of complex molecular architectures. It is primarily needed by R&D and process chemists in the pharmaceutical and agrochemical industries for applications such as Suzuki-Miyaura cross-coupling reactions and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for the formation of carbon-carbon bonds, essential for constructing biaryl and heterobiaryl structures.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and library synthesis to explore structure-activity relationships (SAR) due to its unique cyclopropyl and fluorine motifs.
• Agrochemical Synthesis: Employed in the development of advanced crop protection agents with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands or organocatalysts used in asymmetric synthesis.
• Material Science Research: Potential building block for organic electronic materials or metal-organic frameworks (MOFs) requiring specific functional group integration.

Basic Information

Product Name	4-((tert-Butoxycarbonyl(Cyclopropyl)Amino)Methyl)-3-Fluorophenylboronic Acid
CAS No.	1704064-03-8
Molecular Formula	C16H23BFNO4
Molecular Weight	323.17 g/mol
Synonyms	[3-Fluoro-4-[[N-(tert-butoxycarbonyl)cyclopropylamino]methyl]phenyl]boronic Acid; 4-[[(tert-Butoxycarbonyl)(cyclopropyl)amino]methyl]-3-fluorobenzeneboronic Acid; 3-Fluoro-4-((N-Boc-cyclopropylamino)methyl)phenylboronic Acid; Boc-Cyclopropylamino-Methyl-3-Fluoro-Phenylboronic Acid; N-Boc-N-Cyclopropyl(3-fluoro-4-boronobenzyl)amine; 1704064-03-8; (4-((N-Boc-cyclopropylamino)methyl)-3-fluorophenyl)boronic acid
EINECS	Contact for details

Quality Control

Our 4-((tert-Butoxycarbonyl(Cyclopropyl)Amino)Methyl)-3-Fluorophenylboronic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for demanding research and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.