Description

4-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-3-Fluorophenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a protected piperazine moiety with a boronic acid group, enabling efficient cross-coupling reactions and targeted molecular assembly. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functional group makes it an ideal reagent for palladium-catalyzed cross-coupling reactions to form biaryl structures, a common motif in medicinal chemistry.
• Peptidomimetic & PROTAC Synthesis: The Boc-protected piperazine acts as a versatile linker or solubilizing group in the design of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs).
• Agrochemical Research: Used in the research and development of new herbicides and fungicides that require specific fluorine-containing aromatic systems.
• Material Science: Potential building block for creating novel organic frameworks or functional polymers with specific electronic properties.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	4-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-3-Fluorophenylboronic Acid
CAS No.	1704064-00-5
Molecular Formula	C17H26BFN2O4
Molecular Weight	352.21 g/mol
Synonyms	(3-Fluoro-4-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)phenyl)boronic acid; 4-((4-Boc-piperazin-1-yl)methyl)-3-fluorobenzeneboronic acid; Boc-Pip-Me-3-F-PhB(OH)2; 3-Fluoro-4-[(4-{[(tert-butoxy)carbonyl]amino}piperidin-1-yl)methyl]benzeneboronic acid (common misnomer); 1-Boc-4-[(3-fluoro-4-boronophenyl)methyl]piperazine; Boc-4-(3-Fluoro-4-boronobenzyl)piperazine; 1704064-00-5; Boronic acid, B-[3-fluoro-4-[[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]methyl]phenyl]-
EINECS	Contact for details

Quality Control

Our production of 4-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-3-Fluorophenylboronic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and prevent degradation. Keep the container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.