Description

3-Fluoro-4-((4-Hydroxypiperidin-1-Yl)Methyl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a reactive boronic acid group for Suzuki-Miyaura cross-coupling reactions with a fluorinated aromatic ring and a hydroxypiperidine moiety, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for targeted therapies and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors, CNS-targeting drugs, and other small molecule therapeutics.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides where the specific fluorinated and heterocyclic structure imparts desired biological activity and metabolic stability.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functional group makes it an ideal coupling partner for forming carbon-carbon bonds with aryl halides, a cornerstone reaction in medicinal and process chemistry.
• Ligand and Catalyst Development: The hydroxypiperidine unit can act as a coordinating site in the design of novel ligands and catalysts for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as organic semiconductors or metal-organic frameworks (MOFs), where its specific geometry and functionality are advantageous.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Serves as a versatile linker or warhead component in the design of bifunctional molecules for targeted protein degradation.

Basic Information

Product Name	3-Fluoro-4-((4-Hydroxypiperidin-1-Yl)Methyl)Phenylboronic Acid
CAS No.	1704063-99-9
Molecular Formula	C12H17BFNO3
Molecular Weight	253.08 g/mol
Synonyms	[3-Fluoro-4-[(4-hydroxypiperidin-1-yl)methyl]phenyl]boronic acid; 1-[4-(Boronol)-2-fluorobenzyl]-4-hydroxypiperidine; 3-Fluoro-4-(4-hydroxypiperidin-1-ylmethyl)benzeneboronic acid; 4-(4-Hydroxypiperidin-1-ylmethyl)-3-fluorophenylboronic acid; 3-Fluoro-4-((4-hydroxypiperidin-1-yl)methyl)benzeneboronic acid; B-[3-Fluoro-4-[(4-hydroxy-1-piperidinyl)methyl]phenyl]boronic acid
EINECS	Contact for details

Quality Control

Our production of 3-Fluoro-4-((4-Hydroxypiperidin-1-Yl)Methyl)Phenylboronic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the exacting standards required for research and scale-up applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.