Description

3-((Dimethylamino)Methyl)-4-Fluorophenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a reactive boronic acid group for Suzuki-Miyaura cross-coupling reactions with a dimethylaminomethyl substituent that can influence solubility and serve as a handle for further modification. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly in the creation of complex fluorinated aromatic structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic rings for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in constructing novel herbicides, fungicides, and insecticides where the fluorophenyl moiety is a common pharmacophore.
• Material Science Research: Employed in the development of advanced organic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying biological pathways.
• Cross-Coupling Reactions: Primarily functions as an arylboronic acid coupling partner in palladium-catalyzed Suzuki-Miyaura reactions to form biaryl and heterobiaryl linkages.

Basic Information

Product Name	3-((Dimethylamino)Methyl)-4-Fluorophenylboronic Acid
CAS No.	1704063-96-6
Molecular Formula	C9H13BFNO2
Molecular Weight	197.02 g/mol
Synonyms	4-Fluoro-3-((dimethylamino)methyl)benzeneboronic acid; (4-Fluoro-3-((dimethylamino)methyl)phenyl)boronic acid; 3-(Dimethylaminomethyl)-4-fluorobenzeneboronic acid; B-(4-Fluoro-3-((dimethylamino)methyl)phenyl)boronic acid; 4-Fluoro-3-(N,N-dimethylaminomethyl)phenylboronic acid; [4-Fluoro-3-(dimethylaminomethyl)phenyl]boronic acid
EINECS	Contact for details

Quality Control

Our 3-((Dimethylamino)Methyl)-4-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.