Description

3-((4-Ethylpiperazin-1-Yl)Methyl)-4-Fluorophenylboronic Acid is a specialized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. This compound matters for its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients and by advanced material scientists developing organic electronic components.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology, leveraging its piperazine and fluorophenyl motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, where the boronic acid functionality allows for the introduction of the fluorinated aromatic segment.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its ability to form stable covalent bonds via cross-coupling.
• Chemical Biology & Proteomics: Acts as a handle for bioconjugation and the development of chemical probes and inhibitors, utilizing the boronic acid group's affinity for diols.
• Catalyst & Ligand Development: Serves as a starting material for synthesizing novel bidentate ligands and organocatalysts for asymmetric synthesis.
• Academic & Contract Research: Essential for methodological development in organic synthesis laboratories within universities and CROs (Contract Research Organizations).

Basic Information

Product Name	3-((4-Ethylpiperazin-1-Yl)Methyl)-4-Fluorophenylboronic Acid
CAS No.	1704063-94-4
Molecular Formula	C13H20BFN2O2
Molecular Weight	266.12 g/mol
Synonyms	[4-Fluoro-3-[(4-ethyl-1-piperazinyl)methyl]phenyl]boronic acid; 3-[(4-Ethylpiperazin-1-yl)methyl]-4-fluorobenzeneboronic acid; 4-Fluoro-3-((4-ethylpiperazin-1-yl)methyl)phenylboronic acid; B-[4-Fluoro-3-[(4-ethyl-1-piperazinyl)methyl]phenyl]boronic acid; 3-((4-Ethylpiperazin-1-yl)methyl)-4-fluorobenzeneboronic acid; Boronic acid, B-[4-fluoro-3-[(4-ethyl-1-piperazinyl)methyl]phenyl]-; 1704063-94-4; 4-Fluoro-3-((4-ethylpiperazin-1-yl)methyl)benzeneboronic acid
EINECS	Contact for details

Quality Control

Our 3-((4-Ethylpiperazin-1-Yl)Methyl)-4-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for sensitive coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and reactivity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
Heavy Metals	<20 ppm
Residue on Ignition	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.