Description

3-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-4-Fluorophenylboronic Acid is a sophisticated bifunctional building block that integrates a protected piperazine moiety with a boronic acid functional group. This molecular architecture is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental to modern pharmaceutical and agrochemical synthesis. It is primarily utilized by medicinal chemists and process development scientists in the research and production of novel active pharmaceutical ingredients (APIs), particularly for constructing complex molecules with specific biological targets.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronic acid group enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, facilitating the construction of biaryl and heterobiaryl scaffolds prevalent in modern drug molecules.
• Protease Inhibitor Development: The piperazine-Boc protected structure is valuable for creating inhibitors of various proteases, a major class of therapeutic targets.
• Kinase Inhibitor Synthesis: Used in building blocks for protein kinase inhibitors, leveraging the fluorine atom and the piperazine group for optimal binding affinity and pharmacokinetic properties.
• Chemical Biology & Probe Development: Employed in the creation of chemical probes for studying biological pathways and target validation due to its versatile reactivity and potential for further functionalization.
• Agrochemical Research: Serves as an intermediate in developing new active ingredients for crop protection with enhanced efficacy and environmental profiles.

Basic Information

Product Name	3-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-4-Fluorophenylboronic Acid
CAS No.	1704063-93-3
Molecular Formula	C17H26BFN2O4
Molecular Weight	352.21 g/mol
Synonyms	4-Fluoro-3-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)benzeneboronic acid; (4-Fluoro-3-(((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)phenyl)boronic acid; 3-((4-Boc-piperazin-1-yl)methyl)-4-fluorobenzeneboronic acid; Boc-Pip-F-PhB(OH)2; 1-Boc-4-((5-borono-2-fluorobenzyl)piperazine; tert-Butyl 4-((5-borono-2-fluorobenzyl)piperazine-1-carboxylate; 1704063-93-3; Boronic acid, B-[4-fluoro-3-[[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]methyl]phenyl]-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced pharmaceutical intermediates. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results are available upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.