Description

4-Fluoro-3-((4-Methylpiperazin-1-Yl)Methyl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a reactive boronic acid group with a substituted piperazine moiety, enabling its use in complex coupling reactions and as a key intermediate for pharmacologically active molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for drug discovery and fine chemical synthesis.

Application

This specialized boronic acid is designed for advanced chemical synthesis, with primary applications including:

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile organoboron reagent for constructing biaryl and heterobiaryl structures, which are common scaffolds in medicinal chemistry.
• Drug Discovery & Medicinal Chemistry: Used in high-throughput screening and library synthesis for lead optimization and structure-activity relationship (SAR) studies.
• Agrochemical Research: Employed in the development of novel herbicides and fungicides that require complex, fluorinated aromatic systems.
• Ligand Synthesis for Catalysis: The piperazine nitrogen atoms can be utilized to create novel ligands for transition metal catalysts.
• Material Science: Potential use in the synthesis of organic electronic materials and metal-organic frameworks (MOFs) due to its conjugated system and coordination sites.

Basic Information

Product Name	4-Fluoro-3-((4-Methylpiperazin-1-Yl)Methyl)Phenylboronic Acid
CAS No.	1704063-92-2
Molecular Formula	C12H18BFN2O2
Molecular Weight	252.10 g/mol
Synonyms	[4-Fluoro-3-[(4-methyl-1-piperazinyl)methyl]phenyl]boronic acid; B-[4-Fluoro-3-[(4-methyl-1-piperazinyl)methyl]phenyl]boronic acid; 4-Fluoro-3-((4-methylpiperazin-1-yl)methyl)benzeneboronic acid; 3-((4-Methylpiperazin-1-yl)methyl)-4-fluorophenylboronic acid; 1704063-92-2; 4-Fluoro-3-((4-methylpiperazin-1-yl)methyl)phenylboronic acid pinacol ester (common protected form); 4-Fluoro-3-(4-methylpiperazin-1-ylmethyl)phenylboronic acid
EINECS	Contact for details

Quality Control

Our production of 4-Fluoro-3-((4-Methylpiperazin-1-Yl)Methyl)Phenylboronic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation, to ensure consistency and reliability for sensitive synthetic applications. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.