Description

4-Fluoro-3-((4-Hydroxypiperidin-1-Yl)Methyl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a reactive boronic acid group with a fluorinated aromatic ring and a hydroxypiperidine moiety, making it a versatile intermediate for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for applications in Suzuki-Miyaura cross-coupling reactions to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for targeted therapies and small molecule inhibitors.
• Agrochemical Research: Used in the development of new pesticides and herbicides with enhanced efficacy and selectivity.
• Material Science: Serves as a monomer or cross-linking agent in the creation of advanced polymers and functional materials.
• Suzuki-Miyaura Cross-Coupling: A pivotal reagent for forming carbon-carbon bonds between aromatic rings, a fundamental reaction in medicinal chemistry.
• Ligand Synthesis: Utilized for constructing complex ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Acts as a building block for creating molecular probes to study biological processes and protein interactions.

Basic Information

Item	Detail
Product Name	4-Fluoro-3-((4-Hydroxypiperidin-1-Yl)Methyl)Phenylboronic Acid
CAS No.	1704063-91-1
Molecular Formula	C₁₂H₁₇BFNO₃
Molecular Weight	253.08 g/mol
Synonyms	[3-Fluoro-4-(4-Hydroxypiperidin-1-ylmethyl)phenyl]boronic Acid; 4-Fluoro-3-[(4-Hydroxypiperidin-1-yl)methyl]benzeneboronic Acid; 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluorobenzyl]piperidin-4-ol (Pinacol Ester); B-[3-Fluoro-4-[(4-hydroxy-1-piperidinyl)methyl]phenyl]boronic Acid; 1704063-91-1; 4-Fluoro-3-(4-hydroxypiperidin-1-ylmethyl)phenylboronic acid
EINECS	Contact for details

Quality Control

Our production of 4-Fluoro-3-((4-Hydroxypiperidin-1-Yl)Methyl)Phenylboronic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development. Each lot is analyzed using advanced techniques like HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.