Description

4-Fluoro-2-((2,2,2-Trifluoroethoxy)Methyl)Phenylboronic Acid is a high-value, multi-fluorinated boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring both aromatic fluorine and a trifluoroethoxymethyl side chain, makes it an essential reagent for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides where the fluorine and trifluoroethoxy groups enhance biological activity and environmental stability.
• Material Science Research: Employed in the development of advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Useful for creating fluorinated probes and tags for studying protein-ligand interactions and cellular imaging.
• Custom Synthesis & Contract Manufacturing: A vital component for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Fluoro-2-((2,2,2-Trifluoroethoxy)Methyl)Phenylboronic Acid
CAS No.	1704063-88-6
Molecular Formula	C9H9BF4O3
Molecular Weight	252.0 g/mol
Synonyms	[4-Fluoro-2-[(2,2,2-trifluoroethoxy)methyl]phenyl]boronic acid; 2-[(2,2,2-Trifluoroethoxy)methyl]-4-fluorobenzeneboronic acid; 4-Fluoro-2-(trifluoroethoxymethyl)phenylboronic acid; (4-Fluoro-2-((2,2,2-trifluoroethoxy)methyl)phenyl)boronic acid; Boronic acid, B-[4-fluoro-2-[(2,2,2-trifluoroethoxy)methyl]phenyl]-; CAS 1704063-88-6
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-((2,2,2-Trifluoroethoxy)Methyl)Phenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, impurity profile, and residual solvent content. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) compliance for pharmaceutical applications, and we can accommodate custom purity specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.