Description

2-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-4-Fluorophenylboronic Acid CAS NO 1704063-84-2 is a sophisticated boronic acid derivative featuring a protected piperazine moiety, designed for advanced synthetic applications. This compound is a critical building block in modern pharmaceutical research, enabling the construction of complex molecules through reliable cross-coupling reactions. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for the formation of carbon-carbon bonds, essential for constructing biaryl and heterobiaryl scaffolds.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the modular synthesis of heterobifunctional molecules designed for targeted protein degradation.
• Peptidomimetic & Macrocycle Synthesis: Facilitates the incorporation of constrained, nitrogen-rich heterocycles into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Research: Employed in the discovery and development of new herbicides and fungicides with novel modes of action.
• Chemical Biology Probe Development: Utilized to create tool compounds for studying enzyme function and protein-protein interactions within biological systems.

Basic Information

Product Name	2-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-4-Fluorophenylboronic Acid
CAS No.	1704063-84-2
Molecular Formula	C₁₇H₂₆BFN₂O₄
Molecular Weight	352.21 g/mol
Synonyms	2-[(4-Boc-piperazin-1-yl)methyl]-4-fluorobenzeneboronic acid; 4-Fluoro-2-[(4-{[(tert-butoxy)carbonyl]amino}piperidin-1-yl)methyl]benzeneboronic acid; 2-((4-(tert-Butoxycarbonyl)piperazin-1-yl)methyl)-4-fluorobenzeneboronic acid; 2-[(4-Boc-piperazin-1-yl)methyl]-4-fluorophenylboronic acid; BOC-piperazinylmethyl-fluorophenylboronic acid; (2-((4-(tert-Butoxycarbonyl)piperazin-1-yl)methyl)-4-fluorophenyl)boronic acid; 1704063-84-2; 4-Fluoro-2-((4-(N-Boc-piperazinyl))methyl)phenylboronic acid
EINECS	Contact for details

Quality Control

Our 2-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-4-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and reactivity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.