Description

4-Fluoro-2-(Pyrrolidin-1-Ylmethyl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a reactive boronic acid group with a fluorinated aromatic ring and a pyrrolidine moiety, making it an essential reagent for constructing complex molecular architectures. This advanced intermediate is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Suzuki-Miyaura Cross-Coupling Reagent: Used to form carbon-carbon bonds for constructing biaryl and heterobiaryl structures, which are common scaffolds in medicinal chemistry.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) explorations to introduce fluorinated aromatic systems and modulate the physicochemical properties of lead compounds.
• Agrochemical Synthesis: Serves as a building block for developing advanced crop protection agents and herbicides.
• Material Science Research: Used in the development of organic electronic materials, ligands for catalysis, and novel polymers.
• Chemical Biology Probes: Facilitates the creation of fluorinated probes and tags for studying biological systems and protein interactions.

Basic Information

Product Name	4-Fluoro-2-(Pyrrolidin-1-Ylmethyl)Phenylboronic Acid
CAS No.	1704063-81-9
Molecular Formula	C₁₁H₁₅BFNO₂
Molecular Weight	223.05 g/mol
Synonyms	[4-Fluoro-2-(pyrrolidin-1-ylmethyl)phenyl]boronic acid; 2-(Pyrrolidin-1-ylmethyl)-4-fluorobenzeneboronic acid; 4-Fluoro-2-(1-pyrrolidinylmethyl)benzeneboronic acid; 1704063-81-9; B-[4-Fluoro-2-(pyrrolidin-1-ylmethyl)phenyl]boronic acid; 4-Fluoro-2-(pyrrolidin-1-ylmethyl)benzeneboronic acid
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-(Pyrrolidin-1-Ylmethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every lot to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.