Description

2-(4-Ethylpiperazin-1-Yl)-5-(Trifluoromethyl)Phenylboronic Acid is a high-value, multi-functional boronic acid derivative designed for advanced synthetic chemistry. This compound is a critical building block in modern pharmaceutical and agrochemical research, enabling the formation of carbon-carbon bonds via the versatile Suzuki-Miyaura cross-coupling reaction. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries to create novel, complex molecules. The presence of both the ethylpiperazine and trifluoromethyl groups makes it a key intermediate for developing bioactive compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances biological activity and metabolic stability.
• Suzuki-Miyaura Cross-Coupling: Serves as a crucial boronic acid partner for palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures, a cornerstone of modern medicinal chemistry.
• Material Science Precursor: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its conjugated aromatic system.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized as a linker or functional handle in the design of bifunctional molecules for targeted protein degradation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale GMP batches.

Basic Information

Item	Details
Product Name	2-(4-Ethylpiperazin-1-Yl)-5-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1704063-78-4
Molecular Formula	C13H18BF3N2O2
Molecular Weight	302.11 g/mol
Synonyms	[2-(4-Ethyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]boronic acid; 2-(4-Ethylpiperazin-1-yl)-5-(trifluoromethyl)benzeneboronic acid; 5-(Trifluoromethyl)-2-(4-ethylpiperazin-1-yl)phenylboronic acid; 1704063-78-4; Boronic acid, B-[2-(4-ethyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]-; 2-(4-Ethylpiperazin-1-yl)-5-(trifluoromethyl)phenylboronic acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Our 2-(4-Ethylpiperazin-1-Yl)-5-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0% w/w
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.