Description

2-(Pyrrolidin-1-Yl)-5-(Trifluoromethyl)Phenylboronic Acid is a high-value, multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, combining a pyrrolidine moiety with a trifluoromethylphenylboronic acid group, makes it an essential reagent for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Suzuki-Miyaura Cross-Coupling: Acts as a versatile boronic acid coupling partner for the formation of carbon-carbon bonds, essential for creating biaryl structures in complex molecules.
• Material Science Research: Employed in the development of advanced organic materials, including organic light-emitting diodes (OLEDs) and liquid crystals.
• Medicinal Chemistry & Drug Discovery: Integral for structure-activity relationship (SAR) studies and the synthesis of compound libraries for high-throughput screening.
• Chemical Biology Probes: Serves as a building block for creating molecular probes used to study biological processes and enzyme functions.

Basic Information

Product Name	2-(Pyrrolidin-1-Yl)-5-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1704063-76-2
Molecular Formula	C11H13BF3NO2
Molecular Weight	259.04 g/mol
Synonyms	[2-(1-Pyrrolidinyl)-5-(trifluoromethyl)phenyl]boronic acid; 2-(Pyrrolidin-1-yl)-5-(trifluoromethyl)benzeneboronic acid; 5-Trifluoromethyl-2-pyrrolidin-1-ylphenylboronic acid; 2-Pyrrolidin-1-yl-5-trifluoromethylphenylboronic acid; Boronic acid, B-[2-(1-pyrrolidinyl)-5-(trifluoromethyl)phenyl]-; 1704063-76-2
EINECS	Contact for details

Quality Control

Every batch of 2-(Pyrrolidin-1-Yl)-5-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with exacting purity and identity specifications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.