Description

4-(Ethoxycarbonyldifluoromethyl)-Phenyl-Boronic Acid Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry. This compound matters as a versatile intermediate for constructing complex molecules via cross-coupling reactions like the Suzuki-Miyaura reaction. Pharmaceutical, agrochemical, and advanced materials researchers need it for the efficient synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluoromethyl and aryl-boronate motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific fluorinated aromatic structures.
• Suzuki-Miyaura Cross-Coupling: A critical reagent for forming carbon-carbon bonds between aromatic rings, enabling the construction of complex biaryl systems in medicinal and materials chemistry.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Advanced Material Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic units are desirable.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and probes for studying biological processes and target engagement.

Basic Information

Item	Detail
Product Name	4-(Ethoxycarbonyldifluoromethyl)-Phenyl-Boronic Acid Pinacol Ester
CAS No.	1683545-35-8
Molecular Formula	C₁₆H₂₁BF₂O₄
Molecular Weight	326.15 g/mol
Synonyms	4-(Ethoxycarbonyl(difluoro)methyl)benzeneboronic acid pinacol ester; [4-(Ethoxycarbonyl-difluoromethyl)phenyl]boronic acid pinacol ester; 4-(1-Ethoxy-2,2,2-trifluoroethyl)phenylboronic acid pinacol ester (common misnomer); 4-Carbethoxydifluoromethylphenylboronic acid pinacol ester; Pinacol 4-(ethoxycarbonyldifluoromethyl)phenylboronate; (4-(Ethoxycarbonyldifluoromethyl)phenyl)boronic acid pinacol ester; B-[4-(Ethoxycarbonyldifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 4-(Ethoxycarbonyldifluoromethyl)-Phenyl-Boronic Acid Pinacol Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.