Description

1H-Indole, 2-(2,6-Dimethoxyphenyl)-3-(Diphenylphosphino)-1-Methyl- is a sophisticated, high-value organophosphorus ligand building block designed for advanced catalytic applications. Its unique indole-phosphine hybrid structure makes it a critical component for developing highly selective and active transition metal catalysts. This compound is essential for researchers and process chemists in the pharmaceutical and fine chemical industries, particularly for complex cross-coupling and asymmetric synthesis reactions where precise ligand control is paramount.

Application

• As a specialized ligand in palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig amination).
• Development of asymmetric catalysts for the synthesis of chiral pharmaceutical intermediates and active ingredients.
• Precursor for the synthesis of custom-designed phosphine ligands with tailored steric and electronic properties.
• Use in academic and industrial R&D for exploring new catalytic methodologies in organic synthesis.
• Potential application in material science for creating novel functionalized polymers or metal-organic frameworks (MOFs).
• Catalyst component for hydrogenation and hydrofunctionalization reactions of complex organic molecules.

Basic Information

Product Name	1H-Indole, 2-(2,6-Dimethoxyphenyl)-3-(Diphenylphosphino)-1-Methyl-
CAS No.	1654755-02-8
Molecular Formula	C29H26NO2P
Molecular Weight	451.50 g/mol
Synonyms	2-(2,6-Dimethoxyphenyl)-3-(diphenylphosphino)-1-methyl-1H-indole; 1-Methyl-2-(2,6-dimethoxyphenyl)-3-(diphenylphosphino)-1H-indole; 3-(Diphenylphosphino)-1-methyl-2-(2,6-dimethoxyphenyl)indole; (1-Methyl-2-(2,6-dimethoxyphenyl)-1H-indol-3-yl)diphenylphosphine; Indole-based phosphine ligand; DMAP-Indole-Phosphine ligand (common abbreviation); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of this high-purity ligand is produced and tested under strict quality management protocols to ensure consistency and performance in sensitive catalytic applications. We guarantee a Certificate of Analysis (COA) with each shipment, detailing key parameters such as purity, identity, and moisture content. Our quality systems support compliance with cGMP standards for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should be flushed with inert gas after each opening to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.