Description

Mavacamten CAS NO 1642288-47-8 is a novel, small-molecule cardiac myosin inhibitor. This compound is of significant commercial and therapeutic importance as a targeted treatment for symptomatic obstructive hypertrophic cardiomyopathy (HCM). It is primarily required by pharmaceutical manufacturers, advanced research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the production of innovative cardiovascular therapeutics.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of prescription drugs targeting obstructive hypertrophic cardiomyopathy.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research tool for studying cardiac muscle contractility and sarcomere function.
• Preclinical and Clinical Development of new cardiovascular disease treatments.
• Process Chemistry & Scale-Up studies for optimizing synthetic routes and manufacturing processes.

Basic Information

Product Name	Mavacamten
CAS No.	1642288-47-8
Molecular Formula	C15H19N3O
Molecular Weight	257.33 g/mol
Synonyms	MYK-461; (S)-2-Hydroxy-N-(4-hydroxy-2,6-dimethylphenyl)-1-(1,2,3,4-tetrahydroisoquinolin-3-yl)propanamide; (3S)-3-Amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid (4-hydroxy-2,6-dimethylphenyl)amide; Camzyos (Brand Name); Mavacamtenum
EINECS	Contact for details

Quality Control

Our Mavacamten is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and strength, meeting the stringent requirements for pharmaceutical intermediates and APIs. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccated environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.10%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.