Description

Pimodivir CAS NO 1629869-44-8 is a potent and selective antiviral compound designed to inhibit the cap-binding function of the PB2 subunit of the influenza virus polymerase complex. This mechanism of action makes it a valuable candidate for the development of novel anti-influenza therapeutics, particularly against strains resistant to neuraminidase inhibitors. It is primarily utilized by pharmaceutical research and development organizations, contract research organizations (CROs), and academic institutions engaged in virology and antiviral drug discovery.

Application

• Antiviral Drug Discovery & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in R&D programs targeting influenza A and B viruses.
• Mechanistic & Biochemical Research: Used to study the influenza virus replication cycle, specifically polymerase activity and host-pathogen interactions.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and toxicity profiles of novel antiviral agents.
• Combination Therapy Research: Investigated for potential synergistic effects when used alongside other antiviral agents like oseltamivir to combat resistant viral strains.
• Diagnostic Development: May be used as a component in developing assays to screen for antiviral susceptibility and resistance.

Basic Information

Product Name	Pimodivir
CAS No.	1629869-44-8
Molecular Formula	C₂₄H₂₈F₂N₆O₂
Molecular Weight	470.52 g/mol
Synonyms	VX-787; (S)-3-((2-(4-(4-(Ethylsulfonyl)piperazin-1-yl)phenyl)propan-2-yl)carbamoyl)-2,6-difluorobenzoic acid; Pimodivir (VX-787); VX 787; BTA-074; JNJ-872; Influenza PB2 Inhibitor VX-787
EINECS	Contact for details

Quality Control

Our Pimodivir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	<10 ppm
Assay	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.