Description

Olinciguat is a potent and selective soluble guanylate cyclase (sGC) stimulator, representing a significant advancement in the field of cardiovascular and pulmonary pharmacology. Its primary value lies in its mechanism of action, which directly targets the nitric oxide-sGC-cyclic GMP pathway to induce vasodilation and exert anti-fibrotic effects. This makes it a critical compound for research and development within the pharmaceutical industry, particularly for investigating novel treatments for conditions like pulmonary arterial hypertension (PAH), heart failure, and systemic hypertension. Researchers and development scientists in global pharmaceutical and biotechnology companies require high-purity Olinciguat CAS NO 1628732-62-6 to support preclinical studies, clinical trials, and analytical method development.

Application

• Pharmaceutical R&D (Primary Use): As a key investigational new drug (IND) candidate for the treatment of pulmonary arterial hypertension (PAH) and chronic heart failure with preserved ejection fraction (HFpEF).
• Mechanistic Studies: Used in biochemical and pharmacological research to study the nitric oxide-sGC-cGMP signaling pathway and its role in vascular smooth muscle relaxation.
• Preclinical Development: Serves as a reference standard and active pharmaceutical ingredient (API) in animal model studies for efficacy, pharmacokinetics, and toxicology profiling.
• Analytical Method Development: Employed as a high-purity standard for developing and validating HPLC, LC-MS, and other analytical techniques in quality control laboratories.
• Chemical Intermediate: May be utilized in the synthesis of more complex molecules or prodrugs based on the sGC stimulator scaffold.

Basic Information

Product Name	Olinciguat
CAS No.	1628732-62-6
Molecular Formula	C23H21FN6O3
Molecular Weight	448.45 g/mol
Synonyms	IW-1973; IW1973; 4-({(4-Carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid; 4-[[[4-Carboxybutyl][2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid; Olinciguat (USAN); BAY-1101042 (former code)
EINECS	Contact for details

Quality Control

Our Olinciguat is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity determination by HPLC, and control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Assay (HPLC)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.