Description

Praliciguat CAS NO 1628730-49-3 is a high-purity, small molecule pharmaceutical intermediate and research chemical. It serves as a critical building block in the development of novel therapeutic agents targeting soluble guanylate cyclase (sGC). This compound is essential for pharmaceutical R&D teams and fine chemical manufacturers engaged in cardiovascular and metabolic disease research.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sGC stimulators for clinical development.
• Research & Development: Used as a reference standard and active compound in preclinical studies for cardiovascular diseases.
• Biochemical Research: Tool compound for investigating the nitric oxide (NO)-sGC-cGMP signaling pathway in cellular models.
• Contract Manufacturing: Supplied to CDMOs for the production of active pharmaceutical ingredients (APIs) under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for pharmacological and mechanistic studies.

Basic Information

Product Name	Praliciguat
CAS No.	1628730-49-3
Molecular Formula	C23H21N5O4
Molecular Weight	431.45 g/mol
Synonyms	IW-1973; 2-[4-[(2-Fluorophenyl)methoxy]phenyl]-4-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-5-carboxylic acid methyl ester; Praliciguat (USAN); IW 1973; UNII-8JQ5607E5F; 8JQ5607E5F
EINECS	Contact for details

Quality Control

Our Praliciguat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR, MS). We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.