Description

Methyl 1-(3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a cyclopropane ring and a pinacol boronate ester functional group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex carbon-carbon bonds. It is an essential building block for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly those requiring the incorporation of a fluorinated, sterically constrained cyclopropane moiety.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the fluorinated cyclopropane structure can enhance biological activity and environmental stability.
• Material Science: Serves as a monomer or functional additive in the creation of advanced polymers and organic electronic materials.
• Chemical Synthesis: A versatile reagent for medicinal chemistry and process R&D, enabling the efficient construction of complex, fluorinated biaryl and heterobiaryl structures via palladium-catalyzed cross-coupling.
• Contract Research & Manufacturing (CRMO): Supplied to service organizations supporting drug discovery and development pipelines for global clients.

Basic Information

Product Name	Methyl 1-(3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarboxylate
CAS No.	1620318-26-4
Molecular Formula	C₁₇H₂₂BFO₄
Molecular Weight	320.17 g/mol
Synonyms	Methyl 1-[3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarboxylate; 1-(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylic acid methyl ester; 3-Fluoro-4-(1-(methoxycarbonyl)cyclopropyl)phenylboronic acid pinacol ester; (3-Fluoro-4-(1-(methoxycarbonyl)cyclopropyl)phenyl)boronic acid pinacol ester; CAS 1620318-26-4; Fluorinated Cyclopropane Pinacol Boronate Ester
EINECS	Contact for details

Quality Control

Our production of Methyl 1-(3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR (¹H and ¹³C), and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality systems are designed to support cGMP compliance for pharmaceutical applications, ensuring traceability and reliability for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.