Description

[S(R)]-n-[(R)-[3,5-Bis(1,1-Dimethylethyl)-4-Methoxyphenyl][2-(Diphenylphosphino)Phenyl]Methyl]-2-Methyl-2-Propanesulfinamide is a high-value, chiral sulfinamide-phosphine hybrid ligand, crucial for enabling asymmetric catalysis in advanced organic synthesis. Its sophisticated structure provides exceptional stereocontrol and chelation properties, making it indispensable for creating enantiomerically pure intermediates. This compound is primarily sought by R&D and process development teams in the pharmaceutical and fine chemical industries for the synthesis of complex chiral molecules.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, oncology, and infectious diseases.
• Asymmetric C-C Bond Formation: Used in cross-coupling and addition reactions to create complex molecular architectures with high enantiomeric excess (ee).
• Catalyst Development & Screening: Serves as a privileged ligand in catalyst libraries for high-throughput screening in drug discovery and process optimization.
• Fine Chemical & Agrochemical Production: Enables the synthesis of enantiopure flavors, fragrances, and advanced agrochemical intermediates.
• Academic & Industrial Research: A valuable tool for methodological development in synthetic organic chemistry and catalysis research.

Basic Information

Item	Details
Product Name	[S(R)]-n-[(R)-[3,5-Bis(1,1-Dimethylethyl)-4-Methoxyphenyl][2-(Diphenylphosphino)Phenyl]Methyl]-2-Methyl-2-Propanesulfinamide
CAS No.	1616688-64-2
Molecular Formula	C38H46NO2PS
Molecular Weight	611.82 g/mol
Synonyms	(R)-DTBM-SEGPHOS Sulfinamide; (R)-[3,5-Bis(tert-butyl)-4-methoxyphenyl][2-(diphenylphosphino)phenyl]methyl]-2-methylpropane-2-sulfinamide; S(R),R-Sulfinamide-DTBM-SEGPHOS; Chiral Sulfinamide-Phosphine Ligand; SEGPHOS-based Sulfinamide; tert-Butanesulfinamide-DTBM-SEGPHOS derivative; Asymmetric Hydrogenation Ligand 1616688-64-2
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced under strict quality protocols to ensure exceptional purity and stereochemical integrity, critical for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing purity (HPLC/Chiral HPLC), enantiomeric excess, and identity confirmation. Our quality system is designed to meet the stringent requirements of GMP and ISO standards for advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or ambient light should be avoided to maintain catalytic activity and purity. The storage area should be cool, dry, and well-ventilated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.