Description

[S(R)]-n-[(S)-[3,5-Bis(1,1-Dimethylethyl)-4-Methoxyphenyl][2-(Diphenylphosphino)Phenyl]Methyl]-2-Methyl-2-Propanesulfinamide is a high-value, chiral sulfinamide-phosphine hybrid ligand, essential for enabling highly selective and efficient asymmetric catalytic transformations. Its sophisticated molecular architecture provides a unique steric and electronic environment, making it a critical component for the synthesis of enantiomerically pure pharmaceutical intermediates and fine chemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors where precise stereochemical control is paramount.

Application

• Asymmetric Catalysis: As a privileged ligand for transition metal-catalyzed reactions, including asymmetric hydrogenation, cross-coupling, and C-H functionalization.
• Pharmaceutical Intermediate Synthesis: For the enantioselective construction of chiral centers in active pharmaceutical ingredients (APIs) and complex natural products.
• Agrochemical Development: In the synthesis of chiral herbicides, fungicides, and plant growth regulators requiring specific biological activity.
• Methodology Research: A key tool for academic and industrial researchers developing new catalytic methodologies and exploring reaction mechanisms.
• Fine Chemical Production: Enabling the commercial-scale production of high-value, enantiopure flavors, fragrances, and electronic chemicals.
• Chiral Auxiliary: Utilized in stoichiometric asymmetric synthesis for the temporary induction of chirality.

Basic Information

Product Name	[S(R)]-n-[(S)-[3,5-Bis(1,1-Dimethylethyl)-4-Methoxyphenyl][2-(Diphenylphosphino)Phenyl]Methyl]-2-Methyl-2-Propanesulfinamide
CAS No.	1616688-63-1
Molecular Formula	C38H46NO2PS
Molecular Weight	611.82 g/mol
Synonyms	(SR)-N-[(S)-[3,5-Di-tert-butyl-4-methoxyphenyl](2-(diphenylphosphino)phenyl)methyl]-2-methylpropane-2-sulfinamide; (SR)-N-[(S)-[3,5-Bis(tert-butyl)-4-methoxyphenyl][2-(diphenylphosphino)phenyl]methyl]-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; t-Bu-Sulfinamide-DPP Ligand; (SR,S)-Sulfinamide-DPP Hybrid Ligand; CAS 1616688-63-1; tert-Butylsulfinamide-DPP ligand derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Our quality management system is designed to support cGMP and ISO standards for materials intended for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. Due to its sensitivity to oxidation and light, prolonged exposure to air or ambient conditions should be avoided. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.