Description

Bay 61-3606 (Hydrochloride) is a potent and selective inhibitor of the spleen tyrosine kinase (Syk), a key signaling molecule involved in immunoreceptor activation. This compound is a critical research tool for investigating inflammatory and autoimmune pathways, offering high specificity for modulating B-cell and Fc receptor signaling. It is primarily utilized by pharmaceutical researchers and discovery scientists in the fields of immunology, oncology, and inflammatory disease.

Application

• Biochemical Research: Used as a selective Syk kinase inhibitor in in vitro enzymatic assays to study kinase activity and inhibition profiles.
• Cellular Signaling Studies: Employed in cell-based models to investigate the role of Syk in B-cell receptor (BCR) and Fc receptor (FcR) signaling pathways.
• Immunology & Inflammation Research: A key tool for probing mechanisms in autoimmune diseases, allergic responses, and chronic inflammatory conditions.
• Drug Discovery & Development: Serves as a pharmacological reference standard and lead compound in the development of novel therapeutics targeting Syk.
• Oncology Research: Applied in studies exploring the involvement of Syk in certain hematological malignancies and solid tumors.

Basic Information

Product Name	Bay 61-3606 (Hydrochloride)
CAS No.	1615197-10-8
Molecular Formula	C₂₀H₂₂ClN₅O₂ • HCl
Molecular Weight	436.34 g/mol
Synonyms	Bay 61-3606 HCl; 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide hydrochloride; Syk Inhibitor VI, Hydrochloride; 6-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]nicotinamide hydrochloride; R406 analog hydrochloride
EINECS	Contact for details

Quality Control

Our Bay 61-3606 (Hydrochloride) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.