Description

Upadacitinib Tartrate is the tartrate salt form of a potent and selective Janus kinase (JAK) inhibitor. This high-purity active pharmaceutical ingredient (API) is critical for the development and manufacturing of targeted immunomodulatory therapies. It is primarily utilized by pharmaceutical companies and research institutions engaged in the production of advanced treatments for autoimmune and inflammatory disorders.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of finished dosage forms, such as tablets and capsules.
• Autoimmune Disease Treatment: Key component in medications targeting conditions like rheumatoid arthritis, psoriatic arthritis, and atopic dermatitis.
• Clinical Research: Used as a reference standard and raw material in preclinical and clinical trial studies.
• Drug Development: Serves as a critical intermediate for further chemical synthesis and novel drug discovery programs focused on JAK pathways.
• Analytical Testing: Employed as a certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	Upadacitinib Tartrate
CAS No.	1607431-21-9
Molecular Formula	C₂₇H₃₆N₆O₇ • C₄H₆O₆
Molecular Weight	666.68 g/mol (free base: 426.52 g/mol)
Synonyms	ABT-494 Tartrate; Rinvoq (API form); (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide Tartrate; Upadacitinib L-Tartrate; UNII-4S79S8K9QK; JAK1 Inhibitor ABT-494 Tartrate
EINECS	Contact for details

Quality Control

Our Upadacitinib Tartrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.